Pharmacophore modelling of 17β-HSD1 enzyme based on active inhibitors and enzyme structure
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چکیده
منابع مشابه
Structure-Based Pharmacophore Design and Virtual Screening for Novel Angiotensin Converting Enzyme 2 Inhibitors
The metallopeptidase Angiotensin Converting Enzyme (ACE) is an important drug target for the treatment of hypertension, heart, kidney, and lung disease. Recently, a close and unique human ACE homologue termed ACE2 has been identified and found to be an interesting new cardiorenal disease target. With the recently resolved inhibitor-bound ACE2 crystal structure available, we have attempted a str...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2009
ISSN: 0303-7207
DOI: 10.1016/j.mce.2008.08.030